Preheat oven to 400.
In a large pot or Dutch oven, melt the butter. Sprinkle with flour and cornstarch, whisk until a paste forms.
Add milk and beer and bring to a simmer.
Sprinkle with mustard powder, chili powder, salt and pepper.
Slowly add the cheese in, about ¼ cup at a time, whisking until well combined before adding more. Reserve about 1 cup of cheese for the topping (a mixture of both cheeses).
Add the dry noodles to the cheese sauce, allowing to cook until just before al dente, not cooked through, stirring occasionally. This will take about 8 minutes.
Pour into a 4 qt baking dish in an even layer.
Top with remaining cheese. Toss panko with melted butter until well coated. Sprinkle panko evenly on the top of the macaroni.
Bake at 400 until panko has browned, about 15 minutes.